We are a biomedical and single-cell genomics lab in the biomedical engineering department of Cornell University (Ithaca, NY). Our mission is to develop and apply genomics-based medicine technologies to study and diagnose infectious and immune-related disease.
We pursue research in two areas: i) We investigate technologies and applications of circulating cell-free DNA in diagnostic medicine. We have developed molecular assays to obtain sequence information from cell-free DNA, and computational methods to classify infectious and immune-related disease from cell-free DNA sequencing data. We have demonstrated applications of these technologies for the monitoring of urinary tract infection, solid-organ transplant rejection, inflammatory bowel disease and graft-versus-host disease. ii) We investigate single-cell and spatial sequencing technologies, including technologies developed in-house, to study infection in native, complex tissues and to spatially profile host-microbiome interactions. Our research brings approaches from biophysics and genomics to biomedicine.